Time dose relationships in endometrial adenocarcinoma: importance of the interval from external pelvic irradiation to surgery

Conference · Thu May 01 00:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6839226

Wilson, J F ^[1]; Cox, J D; Chahbazian, C M; del Regato, J A

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1. Medical Coll. of Wisconsin, Milwaukee

One hundred twenty-one patients with adenocarcinoma of the endometrium received external pelvic irradiation (EPI) as a preoperative surgical adjuvant to total abdominal hysterectomy between March, 1951 and February, 1977. Either 400 KVP x-rays, Cobalt teletherapy or 25 MeV photons were used. In more than one third of the hysterectomy specimens, there was no histopathological evidence of residual cancer. Statistical analysis shows a significant reduction in the proportion of positive specimens as the interval to hysterectomy increased. The data support the concept that adenocarcinomas are not radioresistant but may be slow to regress following irradiation. Caution is advised against making decisions about therapy based on histopathological findings in patients who receive surgery immediately following short course or intracavitary preoperative irradiation.

• OSTI ID: 6839226
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:5; Conference: 20. annual scientific assembly of the American Society of Therapeutic Radiologists, Los Angeles, CA, USA, 3 Nov 1978
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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RADIOSENSITIVITY
PELVIS
BIOLOGICAL RADIATION EFFECTS
UTERUS
COBALT 60
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DATA
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ELECTROMAGNETIC RADIATION
FEMALE GENITALS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
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MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
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