Acute phenylbutazone intoxication in the mature horse: a morphological, ultrastructural and biochemical study

Thesis/Dissertation · Thu Jan 01 00:00:00 EST 1987

OSTI ID:6837784

Meschter, C L

Phenylbutazone (PB) administered to adult horses at a dose of 13.46 mg PB/kg bodyweight produces gastrointestinal ulceration by 24 hours and renal crest necrosis by 48 hours. In the gastrointestinal tract, PB initially causes a microvascular lesion characterized ultrastructurally by swelling, lysis, and necrosis of the microvascular endothelial cells. Damage to the endothelium results in microhemorrhage, stasis, and thrombosis. Necrosis and then sloughing of the surrounding tissue follows. This results in mucosal ulceration. In the kidney, damage to the medullary interstitial cell is initially characterized by intracellular vacuolization and cytoplasmic swelling. Necrosis and infiltration neutrophilic leukocytes of the medullary interstitium then occurs and sloughing of the renal crest follows. The uptake of radiolabeled calcium is increased in the kidney and duodenum indicating that cell damage occurs. In cultured equine aortic endothelial and bovine aortic endothelial cells, Pb causes a dose-dependent decrease in lactic dehydrogenase and alkaline phosphatase activity.

• Research Organization: Cornell Univ., Ithaca, NY (USA)
• OSTI ID: 6837784
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTIPYRETICS
TOXICITY
GASTROINTESTINAL TRACT
ULTRASTRUCTURAL CHANGES
KIDNEYS
NECROSIS
ALKALINE PHOSPHATASE
DOSE-RESPONSE RELATIONSHIPS
ENDOTHELIUM
HORSES
OXIDOREDUCTASES
ULCERS
ANIMAL TISSUES
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIGESTIVE SYSTEM
DRUGS
ENZYMES
ESTERASES
HYDROLASES
MAMMALS
MORPHOLOGICAL CHANGES
ORGANS
PATHOLOGICAL CHANGES
PHOSPHATASES
TISSUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques