Comparison of (/sup 14/C)-deoxyglucose metabolism and peripheral benzodiazepine receptor binding in rat C6 glioma

Journal Article · Mon Aug 01 00:00:00 EDT 1988 · Neurology; (United States)

OSTI ID:6837625

Richfield, E K; Ciliax, B J; Starosta-Rubinstein, S R; McKeever, P E; Penney, J B; Young, A B

A rat C6 glioma tumor model has demonstrated that C6 tumor cells express a high density of peripheral benzodiazepine (BDZ) receptors. We report a poor correlation between the density of peripheral BDZ receptors and tumor metabolism using (/sup 14/C)-deoxyglucose in this C6 glioma model. We also compared the abilities of in vivo and in vitro BDZ receptor binding and tumor metabolism to measure the tumor area. All imaging methods were capable of estimating both the gross and total tumor area and had similar specificities and sensitivities. Because of a high signal-to-noise ratio, in vivo peripheral BDZ receptor binding may be a useful method for determining tumor size in human tumors expressing the receptor using PET.

• Research Organization: Univ. of Michigan, Ann Arbor (USA)
• OSTI ID: 6837625
• Journal Information: Neurology; (United States), Vol. 38:8
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
GLIOMAS
DIAGNOSIS
GLUCOSE
METABOLISM
RECEPTORS
BIOCHEMICAL REACTION KINETICS
TRANQUILIZERS
BIOLOGICAL MODELS
CARBON 14 COMPOUNDS
COMPARATIVE EVALUATIONS
IN VITRO
IN VIVO
POSITRON COMPUTED TOMOGRAPHY
RATS
SIGNAL-TO-NOISE RATIO
TUMOR CELLS
ALDEHYDES
ANIMAL CELLS
ANIMALS
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
HEXOSES
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MONOSACCHARIDES
NEOPLASMS
ORGANIC COMPOUNDS
PROTEINS
PSYCHOTROPIC DRUGS
REACTION KINETICS
RODENTS
SACCHARIDES
TOMOGRAPHY
VERTEBRATES
550501* - Metabolism- Tracer Techniques
550601 - Medicine- Unsealed Radionuclides in Diagnostics