Effects of temperature on flow and filtration of blood in a hollow fiber bundle
The hollow fiber bundle is a reasonable physical model for microvascular flow, filtration and permeability characteristics, when using physiological saline solutions and varying amounts of albumin. This model was used to test the rheologic properties of whole pig blood at various hematocrits (HCT), and to determine the effects of temperature (38/sup 0/, 22/sup 0/, 4/sup 0/C) on those rheologic properties. Dilutions of blood with phosphate buffered saline (PBS) were used to measure flow, filtration (CFC) and reabsorption at constant perfusion pressure (82 cm H/sub 2/O), and calculations of resistance to flow (R) and capillary pore resistance (CPR) were made from some of these measurements. Flow and CFC were inversely proportional to HCT. CFC was positively correlated with flow. Reabsorption, flow resistance and CPR were positively correlated with HCT. CPR was 100-2000 X the flow resistance. Low temperature diminished the absolute values of flow and filtration (CFC). Standardization of blood flow with PBS flow did not alter the significant effects of temperature. However, when CFC at any temperature was standardized with the CFC for PBS, temperature had no effect on CFC. These data indicate that where formed cells are excluded (pores), the main cause of cold-induced resistance to flow may be increased viscosity of the solvent. However, within the lumen, cold causes solvent-independent changes in flow, which must involve either formed-cell changes or alterations in the nature of the solutes.
- Research Organization:
- Army Research Institute of Environmental Medicine, Natick, MA
- OSTI ID:
- 6831528
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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BLOOD
FILTRATION
BLOOD FLOW
TEMPERATURE EFFECTS
ANIMAL TISSUES
BIOLOGICAL MODELS
BLOOD COUNT
SWINE
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
DOMESTIC ANIMALS
MAMMALS
MATERIALS
SEPARATION PROCESSES
TISSUES
VERTEBRATES
560200* - Thermal Effects