Prophylaxis of radiation dermatitis with a topical cortisone cream
Nineteen cancer patients receiving radiation therapy to the head, neck, chest wall, or abdomen were evaluated in a double-blind study to determine the effectiveness of 0.2% hydrocortisone valerate vs. placebo in reducing acute radiation dermatitis. Patients applied hydrocortisone valerate to one-half of the irradiated area and the placebo to the other half beginning two weeks after the initiation of radiotherapy and continuing until three weeks after completion. Left and right sides were scored each week with respect to erythema, dry desquamation, moist desquamation, ulceration, and the duration and intensity of symptoms such as soreness, burning, and itching. No statistically significant difference was found between the 0.2% hydrocortisone valerate and the placebo in the acute skin response or the symptoms of radiation dermatitis. The patients were evaluated three months following radiotherapy for evidence of skin atrophy. There were no differences found between hydrocortisone valerate and the placebo with respect to the late effects of radiation therapy.
- Research Organization:
- M.S. Hershey Medical Center, Pennsylvania State University
- OSTI ID:
- 6816011
- Journal Information:
- Radiology; (United States), Vol. 143:3
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
RADIODERMATITIS
POST-IRRADIATION THERAPY
RADIOTHERAPY
SIDE EFFECTS
DELAYED RADIATION EFFECTS
HYDROCORTISONE
LOCAL IRRADIATION
NEOPLASMS
PATIENTS
SKIN
ADRENAL HORMONES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CORTICOSTEROIDS
DERMATITIS
DISEASES
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
INJURIES
IRRADIATION
KETONES
LOCAL RADIATION EFFECTS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PREGNANES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
SKIN DISEASES
STEROID HORMONES
STEROIDS
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)