Influence of conditioned psychological stress on immunological recovery in mice exposed to low-dose x irradiation

Journal Article · Tue May 01 00:00:00 EDT 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576245· OSTI ID:6815872

Sato, K; Flood, J F; Makinodan, T

A study was initiated to determine the effects of psychological stress on the immune response in BALB/c mice recovering from exposure to a low dose of ionizing radiation. Mice were first subjected to conditioning training for 12 days, then exposed to 200 R, subjected to psychological stress for 14 days, and assessed for peak anti-sheep RBC response. The seven treatment groups included two unirradiated groups and five irradiated groups. Mice exposed to 200 R and then subjected to conditioned psychological stress responded less vigorously to antigenic stimulation than those of the other irradiated groups. The psychological stress imposed upon these mice did not influence the antibody-forming capacity of unirradiated mice. These results indicate that a psychological stress which did not affect the immunological activity of unirradiated mice can curtail the immunological recovery of mice exposed to low doses of ionizing radiation.

• Research Organization: Geriatric Research, Education and Clinical Center, Los Angeles, CA
• OSTI ID: 6815872
• Journal Information: Radiat. Res.; (United States), Vol. 98:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL STRESS
RADIOSENSITIVITY EFFECTS
IMMUNITY
BIOLOGICAL RADIATION EFFECTS
MICE
LOW DOSE IRRADIATION
ANTIBODY FORMATION
PSYCHOLOGY
SPLEEN CELLS
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals