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Title: Metabolites of three structural isomers of butylbenzene in the bile of rainbow trout

Abstract

In an ongoing study of the fate of petroleum hydrocarbons in fish, the authors have examined the petroleum derived metabolites which concentrate in the gall bladder bile of cunners, and rainbow trout. The metabolites obtained from the bile of rainbow trout exposed to a petroleum oil have been analyzed by GLC-MS, and several two- and three-ring aromatic alcohols were identified after hydrolysis with {beta}-glucuronidase. Another approach toward the elucidation of the structure of metabolites derived from No. 2 fuel oil relied on chemical synthesis. In another series of experiments, they investigated the type of metabolites obtained in the bile of trout exposed to three n-alkylbenzenes. Exposure of fish to a mixture containing equal amounts of these three n-alkylbenzenes showed their presence in the bile, in a ratio of 1:3:4, for n-butylbenzene, n-hexylbenzene and n-octylbenzene metabolites, respectively. The present exposure was undertaken to determine if, given aromatic hydrocarbons of same molecular weight and ring structure, a relationship could be found between the type of alkyl side chain and metabolites formed; and the influence of the amount of hydrocarbon administered during an exposure on the type of glucuronides formed. Three structural isomers of butylbenzene were chosen for the present experiment: n-butylbenzene, sec-butylbenzenemore » and tert-butylbenzene.« less

Authors:
; ;  [1]
  1. Dept. of Fisheries and Oceans, St. John's, Newfoundland (Canada)
Publication Date:
OSTI Identifier:
6808495
Resource Type:
Journal Article
Journal Name:
Bulletin of Environmental Contamination and Toxicology; (USA)
Additional Journal Information:
Journal Volume: 44:3; Journal ID: ISSN 0007-4861
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AROMATICS; ISOMERS; PETROLEUM; UPTAKE; TROUT; METABOLISM; BENZENE; BILE; GAS CHROMATOGRAPHY; LIQUID COLUMN CHROMATOGRAPHY; METABOLITES; ANIMALS; AQUATIC ORGANISMS; BIOLOGICAL MATERIALS; BODY FLUIDS; CHROMATOGRAPHY; ENERGY SOURCES; FISHES; FOSSIL FUELS; FUELS; HYDROCARBONS; MATERIALS; ORGANIC COMPOUNDS; SEPARATION PROCESSES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Hellou, J, Ryan, A, and Hodder, H J. Metabolites of three structural isomers of butylbenzene in the bile of rainbow trout. United States: N. p., 1990. Web. doi:10.1007/BF01701234.
Hellou, J, Ryan, A, & Hodder, H J. Metabolites of three structural isomers of butylbenzene in the bile of rainbow trout. United States. https://doi.org/10.1007/BF01701234
Hellou, J, Ryan, A, and Hodder, H J. 1990. "Metabolites of three structural isomers of butylbenzene in the bile of rainbow trout". United States. https://doi.org/10.1007/BF01701234.
@article{osti_6808495,
title = {Metabolites of three structural isomers of butylbenzene in the bile of rainbow trout},
author = {Hellou, J and Ryan, A and Hodder, H J},
abstractNote = {In an ongoing study of the fate of petroleum hydrocarbons in fish, the authors have examined the petroleum derived metabolites which concentrate in the gall bladder bile of cunners, and rainbow trout. The metabolites obtained from the bile of rainbow trout exposed to a petroleum oil have been analyzed by GLC-MS, and several two- and three-ring aromatic alcohols were identified after hydrolysis with {beta}-glucuronidase. Another approach toward the elucidation of the structure of metabolites derived from No. 2 fuel oil relied on chemical synthesis. In another series of experiments, they investigated the type of metabolites obtained in the bile of trout exposed to three n-alkylbenzenes. Exposure of fish to a mixture containing equal amounts of these three n-alkylbenzenes showed their presence in the bile, in a ratio of 1:3:4, for n-butylbenzene, n-hexylbenzene and n-octylbenzene metabolites, respectively. The present exposure was undertaken to determine if, given aromatic hydrocarbons of same molecular weight and ring structure, a relationship could be found between the type of alkyl side chain and metabolites formed; and the influence of the amount of hydrocarbon administered during an exposure on the type of glucuronides formed. Three structural isomers of butylbenzene were chosen for the present experiment: n-butylbenzene, sec-butylbenzene and tert-butylbenzene.},
doi = {10.1007/BF01701234},
url = {https://www.osti.gov/biblio/6808495}, journal = {Bulletin of Environmental Contamination and Toxicology; (USA)},
issn = {0007-4861},
number = ,
volume = 44:3,
place = {United States},
year = {Thu Mar 01 00:00:00 EST 1990},
month = {Thu Mar 01 00:00:00 EST 1990}
}