Determination of organic chemicals in human whole blood: Preliminary method development for volatile organics
- Midwest Research Institute, Kansas City, MO (USA)
- Environmental Protection Agency, Washington, DC (USA)
Extensive commercial, industrial, and domestic use of volatile organic chemicals, virtually assures that the general population will be exposed to some level of this class of chemicals. Because blood interacts with the respiratory system and is a major component of the body, it is likely that the analysis of blood will show exposure to volatile organics. Monitoring of the blood in conjunction with monitoring of xenobiotic levels in urine and adipose tissue is an effective way to assess the total body burden resulting from exposure to a chemical. This article introduces a method for the detection and confirmation of selected volatile organics at parts-per-trillion (ppt) levels in whole human blood. Intended for routine use, the method consists of a dynamic headspace purge of water-diluted blood where a carrier gas sweeps the surface of the sample and removes a quantifiable amount of the volatile organics from the blood and into an adsorbent trap. The organics are thermally desorbed from the adsorbent trap and onto the analytical column in a gas-chromatographic/mass-spectrometric (GC/MS) system where limited mass-scan data are taken for qualitative and quantitative identification. Method validation results and limited population-survey results are also presented here.
- OSTI ID:
- 6808453
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 40:5; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD
QUANTITATIVE CHEMICAL ANALYSIS
VOLATILE MATTER
BLOOD CHEMISTRY
AROMATICS
GAS CHROMATOGRAPHY
MASS SPECTROSCOPY
XENOBIOTICS
BIOLOGICAL MATERIALS
BODY FLUIDS
CHEMICAL ANALYSIS
CHROMATOGRAPHY
MATERIALS
MATTER
ORGANIC COMPOUNDS
SEPARATION PROCESSES
SPECTROSCOPY
560300* - Chemicals Metabolism & Toxicology