Insulin resistance and delayed clearance of peptide hormones in cirrhotic rat liver
Clearance of porcine insulin, glucagon, and human growth hormone was measured in intact perfused cirrhotic and normal rat livers. Binding and degradation of /sup 125/I-insulin by hepatocytes isolated from cirrhotic and normal livers were also studied. The half-lives (t/sub 1/2/) of immunoreactive insulin and glucagon were 14.0 +/- 3.1 and 9.6 +/- 2.1 min in normal livers and 26.0 +/- 6.1 and 25.0 +/- 7.1 min in cirrhotic livers. Insulin binding and degradation by hepatocytes from control and cirrhotic livers showed no significant differences. Intraportal insulin infusion in perfusion studies suppressed glucagon-stimulated increases in glucose output from control livers but failed to suppress glucose production by cirrhotic livers, suggesting the presence of hepatic insulin resistance in cirrhosis. Impaired clearance of insulin and glucagon by the intact cirrhotic liver and normal binding and degradation of insulin by isolated hepatocytes suggest that factors such as intrahepatic fibrosis and shunting and postbinding defects may be responsible for the impaired hormone clearance and hepatic insulin resistance.
- Research Organization:
- Univ. of Tennessee, Memphis (USA)
- OSTI ID:
- 6801525
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 252:6
- Country of Publication:
- United States
- Language:
- English
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LABELLED COMPOUNDS
BIODEGRADATION
CLEARANCE
LIVER
BIOLOGICAL FUNCTIONS
PEPTIDE HORMONES
FIBROSIS
GLUCAGON
GLUCOSE
INJURIES
INSULIN
IODINE 125
LIVER CELLS
LIVER CIRRHOSIS
PERFUSED TISSUES
SWINE
ALDEHYDES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
FUNCTIONS
GLANDS
HEXOSES
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
MONOSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOISOTOPES
SACCHARIDES
SOMATIC CELLS
TISSUES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques