Recovery of hematopoietic colony-forming cells in irradiated mice pretreated with interleukin 1 (IL-1)

Journal Article · Sat Oct 01 00:00:00 EDT 1988 · Exp. Hematol.; (United States)

OSTI ID:6796881

Schwartz, G N; Neta, R; Vigneulle, R M; Patchen, M L; MacVittie, T J

Data in this report determined the effect of a single injection of recombinant interleukin 1 alpha (rIL-1) prior to irradiation of B6D2F1 mice on the recovery of colony-forming cells (CFC) at early and late times after sublethal and lethal doses of radiation. Injection of rIL-1 promoted an earlier recovery of mature cells in the blood and CFC in the bone marrow and spleen. For example, 8 days after 6.5 Gy irradiation, the number of CFU-E (colony-forming units-erythroid), BFU-E (burst-forming units-erythroid), and GM-CFC (granulocyte-macrophage colony-forming cells) per femur was approximately 1.5-fold higher in rIL-1-injected mice than in saline-injected mice. Also, 5, 9, and 12 days after irradiation, the number of both day 8 and day 12 CFU-S (colony-forming units-spleen) was almost twofold greater in bone marrow from rIL-1-injected mice. The earlier recovery of CFU-S in rIL-1-injected mice was not associated with an increase in the number of CFU-S that survived immediately after irradiation. Also, 7 months after irradiation, the number of CFU-S per femur of both saline- and rIL-1-injected mice was still less than 50% of normal values. Data in this report demonstrate that a single injection of rIL-1 prior to irradiation accelerates early hematopoietic recovery in irradiated mice, but does not prevent expression of radiation-induced frontend damage or long-term damage to hematopoietic tissues.

• Research Organization: Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
• OSTI ID: 6796881
• Journal Information: Exp. Hematol.; (United States), Vol. 16:9
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHOKINES
RADIOSENSITIVITY EFFECTS
STEM CELLS
BIOLOGICAL RECOVERY
BONE MARROW
COLONY FORMATION
MICE
MORTALITY
RADIATION CHIMERAS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CHIMERAS
GROWTH FACTORS
HEMATOPOIETIC SYSTEM
MAMMALS
MITOGENS
MOSAICISM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RECOVERY
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals