A neutral lipophilic technetium-99m complex for regional cerebral blood flow imaging

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6793220

Narra, R K; Nunn, A D; Kuczynski, B L; DiRocco, R J; Feld, T; Silva, D A; Eckelman, W C ^[1]

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1. Squibb Institute for Medical Research, New Brunswick, NJ (USA)

Technetium-99m-DMG-2MP (Chloro(bis(2,3-butanedionedioxime(1-)-0)(2,3- butanedionedioximato (2-)-N,N{prime},N{double prime},N{prime}{double prime},N{double prime}{double prime},N{prime}{double prime}{double prime}) (2-methylpropyl borato (2-))technetium)), also known as SQ 32097 is a member of a family of neutral lipophilic compounds generally known as boronic acid adducts of technetium dioxime complexes (BATOs). After i.v. administration, the concentration of ({sup 99m}Tc)DMG-2MP in various regions of the brain appears to be proportional to blood flow. In rats, 1.1% ID was in the brain at 5 min postinjection when the blood contained less than 3% ID. Over 24 hr excretion was 59% in the feces and 23% in the urine. The activity in monkey brain at 5 min was 2.8% ID and it cleared with a t1/2 of 86 min. Autoradiographs of monkey brain sections showed excellent regional detail with a gray/white ratio of 3.6 at 10 min. The distribution of ({sup 99m}Tc)DMG-2MP in the monkey brain corresponds to the known cytoarchitectural pattern of cerebral glucose metabolism. The properties of ({sup 99m}Tc)DMG-2MP make it a potentially useful agent for cerebral perfusion imaging in man.

• OSTI ID: 6793220
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:8; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CEREBRAL CORTEX
BLOOD FLOW
GLUCOSE
METABOLISM
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
AUTORADIOGRAPHY
BRAIN
ISOMERIC NUCLEI
MONKEYS
PERFUSED ORGANS
RATS
TECHNETIUM 99
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CEREBRUM
DISTRIBUTION
DRUGS
HEXOSES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPES
RODENTS
SACCHARIDES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics