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Title: Total lymphoid irradiation in rat heart albgrafts: dose, fractionation, and combination with cyclosporin-A. [X-ray]

Abstract

The survival or organ allografts is prolonged in mice and rats treated with fractionated, high-dose total lymphoid irradiation (TLI). We have studied the effect of TLI, alone or in combination with donor bone marrow or pharmacologic immunosuppression (cyclosporin-A: CY-A), on the survival of heterotopic rat heart allografts. Specifically, we evaluated the generalized immunosuppressive effect of TLI as a function of accumulated dose and fractionation schedule. In addition, TLI and CY-A were used individually in schedules that by themselves gave only moderate graft prolongation and then subsequently in sequential combination.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Univ. of Minnesota Health Sciences Center, Minneapolis
OSTI Identifier:
6792656
Resource Type:
Conference
Journal Name:
Transplant. Soc., Int. Cong., Proc.; (United States)
Additional Journal Information:
Journal Volume: 13:1; Conference: 8. international congress of the Transplantation Society, Boston, MA, USA, 29 Jun 1980
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FRACTIONATED IRRADIATION; EVALUATION; GRAFTS; BIOLOGICAL RADIATION EFFECTS; HEART; IMMUNOSUPPRESSION; RADIOINDUCTION; IMMUNOSUPPRESSIVE DRUGS; RADIATION DOSES; X RADIATION; DOSE-RESPONSE RELATIONSHIPS; BONE MARROW CELLS; LYMPH NODES; PARTIAL BODY IRRADIATION; RATS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CARDIOVASCULAR SYSTEM; CONNECTIVE TISSUE CELLS; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; LYMPHATIC SYSTEM; MAMMALS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; TRANSPLANTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Rynasiewicz, J J, Sutherland, D E.R., Kawahara, K, Kim, T, and Najarian, J S. Total lymphoid irradiation in rat heart albgrafts: dose, fractionation, and combination with cyclosporin-A. [X-ray]. United States: N. p., 1981. Web.
Rynasiewicz, J J, Sutherland, D E.R., Kawahara, K, Kim, T, & Najarian, J S. Total lymphoid irradiation in rat heart albgrafts: dose, fractionation, and combination with cyclosporin-A. [X-ray]. United States.
Rynasiewicz, J J, Sutherland, D E.R., Kawahara, K, Kim, T, and Najarian, J S. 1981. "Total lymphoid irradiation in rat heart albgrafts: dose, fractionation, and combination with cyclosporin-A. [X-ray]". United States.
@article{osti_6792656,
title = {Total lymphoid irradiation in rat heart albgrafts: dose, fractionation, and combination with cyclosporin-A. [X-ray]},
author = {Rynasiewicz, J J and Sutherland, D E.R. and Kawahara, K and Kim, T and Najarian, J S},
abstractNote = {The survival or organ allografts is prolonged in mice and rats treated with fractionated, high-dose total lymphoid irradiation (TLI). We have studied the effect of TLI, alone or in combination with donor bone marrow or pharmacologic immunosuppression (cyclosporin-A: CY-A), on the survival of heterotopic rat heart allografts. Specifically, we evaluated the generalized immunosuppressive effect of TLI as a function of accumulated dose and fractionation schedule. In addition, TLI and CY-A were used individually in schedules that by themselves gave only moderate graft prolongation and then subsequently in sequential combination.},
doi = {},
url = {https://www.osti.gov/biblio/6792656}, journal = {Transplant. Soc., Int. Cong., Proc.; (United States)},
number = ,
volume = 13:1,
place = {United States},
year = {Sun Mar 01 00:00:00 EST 1981},
month = {Sun Mar 01 00:00:00 EST 1981}
}

Conference:
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