Chromosomal localization of the human heme oxygenase genes: Heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13. 3

Journal Article · Fri Apr 01 00:00:00 EST 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1213· OSTI ID:6789335

Kutty, R K; Kutty, G; Rodriguez, I R; Chader, G J; Wiggert, B ^[1]

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1. National Institutes of Health, Bethesda, MD (United States)

Heme oxygenase catalyzes the oxidation of heme to biliverdin, the precursor of the bile pigment bilirubin, and carbon monoxide, a putative neurotransmitter. The authors have employed polymerase chain reaction and fluorescence in situ hybridization to determine the chromosome localization of the genes coding for the two known heme oxygenase isozymes. Heme oxygenase-1 (HMOX1), the inducible form, was localized to human chromosome 22q12, while heme oxygenase-2 (HMOX2), the constitutive form, was localized to chromosome 16p13.3. 14 refs., 3 figs.

• OSTI ID: 6789335
• Journal Information: Genomics; (United States), Vol. 20:3; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HEME
OXIDATION
HUMAN CHROMOSOME 16
GENETIC MAPPING
HUMAN CHROMOSOME 22
OXYGENASES
GENES
DNA HYBRIDIZATION
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
CHROMOSOMES
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PIGMENTS
PORPHYRINS
PROTEINS
550400* - Genetics