Dynamic biological exposure indexes for n-hexane and 2,5-hexanedione, suggested by a physiologically based pharmacokinetic model

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · American Industrial Hygiene Association Journal; (USA)

DOI:https://doi.org/10.1080/15298669091369781· OSTI ID:6788373

Perbellini, L; Mozzo, P; Olivato, D

Biological exposure index (BEI) of n-hexane was studied for accuracy using a physiologically based pharmacokinetic (PB-PK) model. The kinetics of n-hexane in alveolar air, blood, urine, and other tissues were simulated for different values of alveolar ventilations and also for constant and variable exposures. The kinetics of 2,5-hexanedione, the toxic n-hexane metabolite, were also simulated. The ranges of n-hexane concentrations in biological media and the urinary concentrations of 2,5-hexanedione are discussed in connection with a mean n-hexane exposure of 180 mg/m3 (50 ppm) (threshold limit value (TLV) suggested by American Conference of Governmental Industrial Hygienists (ACGIH) for 1988-89). The experimental and field data as well as those predicted by simulation with the PB-PK model were comparable. The physiological-pharmacokinetic simulations are used to propose the dynamic BEIs of n-hexane and 2,5-hexanedione. The use of simulation with PB-PK models enables a better understanding of the limits, advantages, and issues associated with biological monitoring of exposures to industrial solvents.

• OSTI ID: 6788373
• Journal Information: American Industrial Hygiene Association Journal; (USA), Vol. 51:7; ISSN 0002-8894
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HEXANE
METABOLISM
ORGANIC SOLVENTS
MAN
MATHEMATICAL MODELS
MAXIMUM PERMISSIBLE EXPOSURE
TISSUE DISTRIBUTION
ALKANES
ANIMALS
DISTRIBUTION
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
PRIMATES
SAFETY STANDARDS
SOLVENTS
STANDARDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology