Thromboxane-mediated injury following radiation. Annual report, 1 September 1984-31 August 1985
The hypothesis under investigation is that moderate levels of radiation exposure result in endothelial and other tissue damage which, in turn, increases in vivo synthesis of thromboxane A2 (TXA2). The observations indicate that the sources of the radiation-induced increases in TXB2 excretion are diverse, involving organs of both the thorax and upper abdomen. This conclusion is based on the attenuation in the radiation-induced increase in TXB2 excretion seen four hours after 20.0-Gy gamma irradiation with either the thorax or abdomen shielded. An isolated perfused rat kidney model was developed to determine if the kidneys contribute to the altered cyclooxygenase product release. Urine from the irradiated isolated kidney system showed an elevated excretion of TXB2, PGE2, and 6KPGFla compared to kidneys from sham-irradiated animals. Whole-body irradiation of rats also increased pulmonary release of TXB2 four hours after exposure. The data show that in vivo release of TXB2 involves more than one organ system and as a result, the use of TXB2 as a biological dosimeter requires knowledge as to the organ systems that were irradiated. These data also suggest that regional release of TXB2 varies and as such may provide a means of evaluating regional radiation injury. The results of the past year show that radiation can alter vascular reactivity to a cyclooxygenase product mimic and that this arachidonate metabolite release is increased following radiation exposure.
- Research Organization:
- Georgetown Univ., Washington, DC (USA). Dept. of Physiology and Biophysics
- OSTI ID:
- 6786695
- Report Number(s):
- AD-A-177824/0/XAB
- Country of Publication:
- United States
- Language:
- English
Similar Records
Thromboxane-mediated injury following radiation. Annual report, 1 September 1985-17 June 1986, Final report 15 January 1984-17 June 1986
Thromboxane-mediated injury following radiation. Annual summary report No. 1, January-September 1984
Related Subjects
DRUGS
BIOLOGICAL EFFECTS
RADIATION INJURIES
ABDOMEN
ANIMALS
BIOLOGY
BIOSYNTHESIS
ENDOTHELIUM
EXCRETION
GAMMA RADIATION
IRRADIATION
KIDNEYS
OXIDOREDUCTASES
RATS
SYNTHESIS
URINE
ANIMAL TISSUES
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL WASTES
BODY
BODY AREAS
BODY FLUIDS
CLEARANCE
ELECTROMAGNETIC RADIATION
ENZYMES
INJURIES
IONIZING RADIATIONS
MAMMALS
MATERIALS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
TISSUES
VERTEBRATES
WASTES
560152* - Radiation Effects on Animals- Animals