Use of ultrafast computed tomography to quantitate regional myocardial perfusion: a preliminary report

Journal Article · Thu Jan 01 00:00:00 EST 1987 · J. Am. Coll. Cardiol.; (United States)

DOI:https://doi.org/10.1016/S0735-1097(87)80083-9· OSTI ID:6782500

Rumberger, J A; Feiring, A J; Lipton, M J; Higgins, C B; Ell, S R; Marcus, M L

The purpose of this study was to assess the potential for rapid acquisition computed axial tomography (Imatron C-100) to quantify regional myocardial perfusion. Myocardial and left ventricular cavity contrast clearance curves were constructed after injecting nonionic contrast (1 ml/kg over 2 to 3 seconds) into the inferior vena cava of six anesthetized, closed chest dogs (n = 14). Independent myocardial perfusion measurements were obtained by coincident injection of radiolabeled microspheres into the left atrium during control, intermediate and maximal myocardial vasodilation with adenosine (0.5 to 1.0 mg/kg per min, intravenously, respectively). At each flow state, 40 serial short-axis scans of the left ventricle were taken near end-diastole at the midpapillary muscle level. Contrast clearance curves were generated and analyzed from the left ventricular cavity and posterior papillary muscle regions after excluding contrast recirculation and minimizing partial volume effects. The area under the curve (gamma variate function) was determined for a region of interest placed within the left ventricular cavity. Characteristics of contrast clearance data from the posterior papillary muscle region that were evaluated included the peak myocardial opacification, area under the contrast clearance curve and a contrast clearance time defined by the full width/half maximal extent of the clearance curve. Myocardial perfusion (microspheres) ranged from 35 to 450 ml/100 g per min (mean 167 +/- 125).

• Research Organization: Univ. of Iowa, Iowa City, IA (United States)
• OSTI ID: 6782500
• Journal Information: J. Am. Coll. Cardiol.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
COMPUTERIZED TOMOGRAPHY
MYOCARDIUM
BLOOD CIRCULATION
ALGORITHMS
CONTRAST MEDIA
DOGS
MICROSPHERES
PERFUSED ORGANS
RADIOISOTOPES
VASODILATION
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
ISOTOPES
MAMMALS
MATHEMATICAL LOGIC
MUSCLES
ORGANS
TOMOGRAPHY
VERTEBRATES
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