Radiation-induced renal damage: the effects of hyperfractionation. [Mice]
The response of mouse kidneys to multifraction irradiation was assessed using three nondestructive functional end points. A series of schedules was investigated giving 1, 2, 4, 8, 16, 32, or 64 equal X-ray doses, using doses per fraction in the range of 0.9 to 16 Gy. The overall treatment time was kept constant at 3 weeks. Kidney function was assessed from 19 to 48 weeks after irradiation by measuring changes in isotope clearance, urine output, and hematocrit. All three assays yielded steep dose-effect curves from which the repair capacity of kidney could be estimated by comparing the isoeffective doses in different schedules. There was a marked influence of fractionation, with increasing dose being required to achieve the same level of damage for increasing fraction number, even between 32 and 64 fractions. The data are well fitted by a linear quadratic dose-response equation, and analysis of the data would suggest that hyperfractionation, using extremely small X-ray doses per fraction, would spare kidneys relative to tumors and acutely responding tissues.
- Research Organization:
- Mount Vernon Hospital, Northwood, England
- OSTI ID:
- 6782432
- Journal Information:
- Radiat. Res.; (United States), Vol. 98:2
- Country of Publication:
- United States
- Language:
- English
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Radition induced renal damage in mice: influence of fraction size
Renal damage in the mouse: the response to very small doses per fraction
Related Subjects
CHROMIUM 51
RENAL CLEARANCE
EDTA
KIDNEYS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL REPAIR
MICE
FRACTIONATED IRRADIATION
ANEMIAS
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
HEMATOLOGY
ISODOSE CURVES
URINE
X RADIATION
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
CHROMIUM ISOTOPES
CLEARANCE
DATA
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
HEMIC DISEASES
INFORMATION
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
MATERIALS
MEDICINE
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RECOVERY
REPAIR
RODENTS
SYMPTOMS
VERTEBRATES
WASTES
560152* - Radiation Effects on Animals- Animals