Interaction of theobromine with sodium benzoate
Journal Article
·
· J. Pharm. Sci.; (United States)
The interaction of theobromine with sodium benzoate was investigated by PMR spectroscopy. The interaction of theobromine with pentadeuterated benzoic acid (benzoic acid-d5) was examined in the same manner but to a lesser degree. Chemical shifts of theobromine protons were determined as a function of sodium benzoate concentration in deuterium oxide at 30 and 15 degrees. Signals of both methyl groups of theobromine underwent significant upfield shifts when sodium benzoate was added to a theobromine solution. This fact suggests that a complex is formed by vertical stacking or plane-to-plane stacking. The same results were obtained for benzoic acid-d5.
- Research Organization:
- Kobe Women's College of Pharmacy, Japan
- OSTI ID:
- 6782189
- Journal Information:
- J. Pharm. Sci.; (United States), Vol. 71:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
BENZOIC ACID
PHARMACOLOGY
THEOBROMINE
CHEMICAL REACTION KINETICS
CHEMICAL SHIFT
SPECTROSCOPY
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
DRUGS
HETEROCYCLIC COMPOUNDS
KINETICS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
REACTION KINETICS
VASODILATORS
XANTHINES
500600* - Environment
Atmospheric- Regulations- (-1989)
BENZOIC ACID
PHARMACOLOGY
THEOBROMINE
CHEMICAL REACTION KINETICS
CHEMICAL SHIFT
SPECTROSCOPY
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
DRUGS
HETEROCYCLIC COMPOUNDS
KINETICS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
REACTION KINETICS
VASODILATORS
XANTHINES
500600* - Environment
Atmospheric- Regulations- (-1989)