Noninvasive quantitative assessment of pacing induced ischemia in coronary artery disease patients using spect imaging with thallium-201

Conference · Sun Jan 01 00:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6779777

Summerville, D A; Polak, J F; Holman, B L; Jaski, B E; Nesto, R W

The authors have investigated the use of a quantification algorithm which measures total myocardial mass using thallium-201 and single photon emission computed tomography (SPECT). Myocardial and lung uptake ratios were determined from the early and redistribution scintigrams of twelve coronary artery disease patients who had received intraventricular thallium-201 during pacing induced ischemia. The Iowa heart phantom placed in an Alderson chest phantom were imaged tomographically for the obtained range in target-to-background ratios. Tomographic acquisitions were made over 180/sup 0/: 30/sup 0/ RAO to 60/sup 0/ LPO for 64 projections. All reconstructions were made using attenuation compensation. Transverse tomographic slices were formatted into oblique data sets. The slices perpendicular to the left ventricular long axis (typically 16 to 19, .62 cm thick) were processed by a previously described algorithm which estimates volumes above certain threshold count values in contiguous slices and then sums according to Simpson's rule. Calibration curves for different target-to-background values and different threshold values were obtained. In the phantom, changes in the refillable chambers were accurately quantifiable. When applied to six patient studies, estimates of the change in myocardial mass correlated with the amount of ischemia (elevation in left ventricular EDP, r = .93). The authors conclude that SPECT can be used to make accurate estimates of myocardial mass using such algorithms if care is taken to adjust for individual variations in the uptake of tahallium-201.

• Research Organization: Brigham and Women's Hospital and Harvard Medical School, Boston, MA
• OSTI ID: 6779777
• Report Number(s): CONF-840619-; TRN: 87-008904
• Journal Information: J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARDIOVASCULAR DISEASES
DIAGNOSIS
CORONARIES
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
THALLIUM 201
DIAGNOSTIC USES
UPTAKE
IMAGE PROCESSING
MYOCARDIUM
PATIENTS
ARTERIES
BETA DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEART
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
TOMOGRAPHY
USES
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics