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Title: Cell population kinetic parameters for acute epidermal reactions in man

Abstract

Cell population kinetic parameters for acute reactions in squamous epithelium were estimated using available data on skin tolerance doses. Roughly equivalent doses for kilovoltage radiation delivered in equal daily fractions, as reported by F. Ellis (Br. J. Radiol. 15, 348-350 (1942)) and by R. Paterson (The Treatment of Malignant Disease by Radium and X-Rays. Edward Arnold, London, 1948), were combined with data for nonstandard fractionation at longer intervals of 1 or 2 weeks. By analyzing the combined data set, well-determined parameters could be derived. The data show that repopulation, with a potential cell doubling time of about 7 days, must occur in irradiated human skin, though this may possibly be limited to no more than seven doublings. The parameters derived are distinctly different from those associated with late-reacting dose-limiting tissues. The main difference is the steeper initial slope of the computed survival curve, that is a larger J parameter (multitarget model) or a larger alpha component (linear-quadratic model).

Authors:
Publication Date:
Research Org.:
Michael Reese Medical Center, Chicago, IL
OSTI Identifier:
6776294
Resource Type:
Journal Article
Journal Name:
Radiat. Res.; (United States)
Additional Journal Information:
Journal Volume: 2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EPITHELIUM; BIOLOGICAL RADIATION EFFECTS; CELL DIVISION; FRACTIONATED IRRADIATION; RADIATION DOSES; SKIN; ANIMAL TISSUES; BIOLOGICAL EFFECTS; BODY; DOSES; IRRADIATION; ORGANS; RADIATION EFFECTS; TISSUES; 560151* - Radiation Effects on Animals- Man

Citation Formats

Cohen, L. Cell population kinetic parameters for acute epidermal reactions in man. United States: N. p., 1986. Web. doi:10.2307/3576819.
Cohen, L. Cell population kinetic parameters for acute epidermal reactions in man. United States. https://doi.org/10.2307/3576819
Cohen, L. 1986. "Cell population kinetic parameters for acute epidermal reactions in man". United States. https://doi.org/10.2307/3576819.
@article{osti_6776294,
title = {Cell population kinetic parameters for acute epidermal reactions in man},
author = {Cohen, L},
abstractNote = {Cell population kinetic parameters for acute reactions in squamous epithelium were estimated using available data on skin tolerance doses. Roughly equivalent doses for kilovoltage radiation delivered in equal daily fractions, as reported by F. Ellis (Br. J. Radiol. 15, 348-350 (1942)) and by R. Paterson (The Treatment of Malignant Disease by Radium and X-Rays. Edward Arnold, London, 1948), were combined with data for nonstandard fractionation at longer intervals of 1 or 2 weeks. By analyzing the combined data set, well-determined parameters could be derived. The data show that repopulation, with a potential cell doubling time of about 7 days, must occur in irradiated human skin, though this may possibly be limited to no more than seven doublings. The parameters derived are distinctly different from those associated with late-reacting dose-limiting tissues. The main difference is the steeper initial slope of the computed survival curve, that is a larger J parameter (multitarget model) or a larger alpha component (linear-quadratic model).},
doi = {10.2307/3576819},
url = {https://www.osti.gov/biblio/6776294}, journal = {Radiat. Res.; (United States)},
number = ,
volume = 2,
place = {United States},
year = {Sat Nov 01 00:00:00 EST 1986},
month = {Sat Nov 01 00:00:00 EST 1986}
}