Prevention of 3-methylcholanthrene-induced fibrosarcomas in rats pre-inoculated with endogenous rat retrovirus

Journal Article · Wed Apr 01 00:00:00 EST 1981 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.78.4.2526· OSTI ID:6769083

Fish, D C ^[1]; Demarais, J T; Djurickovic, D B; Huebner, R J

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1. Frederick Cancer Research Center, MD

Weanling Fischer 344 rats received a single intraperitoneal injection of a 1000-fold concentrated preparation of endogenous nontransforming rat retrovirus. Ten days later, the rats were each given a single subcutaneous injection of 3-methylcholanthrene. The rats inoculated with the endogenous rat retrovirus were significantly protected against the development of cancer, whereas uninoculated rats and rats given one of several murine tetroviruses or baboon retrovirus were not protected.

• OSTI ID: 6769083
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 78:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
3-METHYLCHOLANTHRENE
TOXICITY
NEOPLASMS
INHIBITION
VIRUSES
INOCULATION
CARCINOGENESIS
IMMUNITY
RATS
ANIMALS
AROMATICS
DISEASES
HYDROCARBONS
MAMMALS
MICROORGANISMS
ORGANIC COMPOUNDS
PARASITES
PATHOGENESIS
POLYCYCLIC AROMATIC HYDROCARBONS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)