Preliminary toxicological study of ferric acetyl acetonate

Technical Report · Sat Jan 01 00:00:00 EST 1983

OSTI ID:6763376

London, J E; Smith, D M

The calculated acute oral LD/sub 50//sup 30/ (lethal does for 50% of the animals occuring with 30 days after compound administration) values for ferric acetyl acetonate were 584 mg/kg in mice and 995 mg/kg in rats. According to classical guidelines, this compound would be considered slightly toxic in both species. Skin application studies in the rabbit demonstrated the compound to be irritating. The eye irritation study disclosed the compound to be a severe irritant causing permanent damage to the cornea (inflammation and scarring resulting in blindness). The sensitization study in the guinea pig did not show ferric acetyl acetonate to be deleterious in this regard.

• Research Organization: Los Alamos National Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6763376
• Report Number(s): LA-9627-MS; ON: DE83007117
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLACETONE
TOXICITY
EXPERIMENTAL DATA
EYES
GUINEA PIGS
INGESTION
IRON COMPOUNDS
ORAL ADMINISTRATION
RABBITS
RATS
SKIN
ANIMALS
BODY
BODY AREAS
CHELATING AGENTS
DATA
FACE
HEAD
INFORMATION
INTAKE
KETONES
MAMMALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
REAGENTS
RODENTS
SENSE ORGANS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)