Molecular genetics in affective illness

Journal Article · Fri Jan 01 00:00:00 EST 1993 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(93)90214-N· OSTI ID:6762106

Mendlewicz, J; Sevy, S; Mendelbaum, K ^[1]

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1. Erasme Univ. Hospital, Brussels (Belgium)

Genetic transmission in manic depressive illness (MDI) has been explored in twins, adoption, association, and linkage studies. The X-linked transmission hypothesis has been tested by using several markers on chromosome X: Xg blood group, color blindness, glucose-6-phosphate dehydrogenase (G6PD), factor IX (hemophilia B), and DNA probes such as DXS15, DXS52, F8C, ST14. The hypothesis of autosomal transmission has been tested by association studies with the O blood group located on chromosome 9, as well as linkage studies on chromosome 6 with the Human Leucocyte Antigens (HLA) haplotypes and on Chromosome 11 with DNA markers for the following genes: D2 dopamine receptor, tyrosinase, C-Harvey-Ras-A (HRAS) oncogene, insuline (ins), and tyrosine hydroxylase (TH). Although linkage studies support the hypothesis of a major locus for the transmission of MDI in the Xq27-28 region, several factors are limiting the results, and are discussed in the present review. 105 refs., 1 fig., 2 tabs.

• OSTI ID: 6762106
• Journal Information: Life Sciences; (United States), Vol. 52:3; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
MENTAL DISORDERS
GENETICS
ANTIGENS
BIOLOGICAL MARKERS
BLOOD GROUPS
CHROMOSOMES
DOPAMINE
EXPERIMENTAL DATA
GENES
GENETIC MAPPING
HUMAN X CHROMOSOME
LEUKOCYTES
RECEPTORS
TYROSINASE
TYROSINE
AMINES
AMINO ACIDS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DATA
DRUGS
ENZYMES
HETEROCHROMOSOMES
HUMAN CHROMOSOMES
HYDROXY ACIDS
HYDROXY COMPOUNDS
HYDROXYLASES
INFORMATION
MAPPING
MATERIALS
MEMBRANE PROTEINS
NEUROREGULATORS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PHENOLS
POLYPHENOLS
PROTEINS
SYMPATHOMIMETICS
X CHROMOSOME
550400* - Genetics