Production of 7. 6-minute potassium-38 for medical use
A method is described for generating 20 to 30 mCi of 7.6-min potassium-38 by means of a small cyclotron. Sodium chloride is mounted on a water-cooled tantalum plate, by evaporation from an aqueous solution. It is bombarded with 14.7-MeV helium-4 ions, at 50 ..mu..A. The K-38 is produced free of other radionuclides. For intravenous injection the bombarded NaCl is dissolved in sufficient pyrogen-free water to make an isotonic saline solution, which then is sterilized by filtration. Other methods of production investigated were the bombardment of: carbon tetrachloride with He-4 ions; calcium oxide with 7.8-MeV deuterons; and potassium chloride with 23-MeV He-3 ions. These gave products that were unsuitable for clinical applications. Chiefly because of the short half-life of K-38, the whole-body radiation exposure is estimated to be only about 12 mrad/mCi, and exposures to the heart and kidneys are approximately ten times greater.
- Research Organization:
- Memorial Sloan-Kettering Cancer Center, New York, NY
- OSTI ID:
- 6760302
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 21:9
- Country of Publication:
- United States
- Language:
- English
Similar Records
Observations of the dynamics of ionic potassium-38 in brain
In vivo assessment of myocardial perfusion and viability by kinetics of potassium-38
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
POTASSIUM 38
PRODUCTION
RADIOPHARMACEUTICALS
BIOLOGICAL HALF-LIFE
CALCIUM OXIDES
CARBON TETRACHLORIDE
CHEMICAL PREPARATION
COMPARATIVE EVALUATIONS
CYCLOTRONS
HEART
HELIUM 3 BEAMS
HELIUM 4 BEAMS
KIDNEYS
POTASSIUM CHLORIDES
RADIATION DOSES
SODIUM CHLORIDES
ACCELERATORS
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
BEAMS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CALCIUM COMPOUNDS
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
CHLORIDES
CHLORINATED ALIPHATIC HYDROCARBONS
CHLORINE COMPOUNDS
CYCLIC ACCELERATORS
DOSES
DRUGS
HALIDES
HALOGEN COMPOUNDS
HALOGENATED ALIPHATIC HYDROCARBONS
ION BEAMS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POTASSIUM COMPOUNDS
POTASSIUM ISOTOPES
RADIOACTIVE MATERIALS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SODIUM COMPOUNDS
SYNTHESIS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials