Human brain development in infants with PET and FDG
The authors used studies of local cerebral metabolic rate for glucose (LCMRGlc) to examine development of cerebral organization in 5 days to 1 year old children. A group (n=8) of infants with diverse pediatric disorders allowed investigation of developmental changes in LCMRGlc, while also providing relevant clinical management information. Patients consisted of questionable and definite neonatal seizures, cerebral embolism from cardiac sources, and otherwise normal infants with facial nevi with consideration of Sturge-Weber. Gradual increase in cortical LCMRGlc coincides with suppression of intrinsic subcortical reflexes present in all newborns. Two retarded children (2 years old) showed LCMRGlc developmental patterns of a few days old, which corresponded to their functional and mental status. These studies illustrate great potential of PET to study normal and altered states of human brain development.
- Research Organization:
- UCLA School of Medicine, Los Angeles, CA
- OSTI ID:
- 6759704
- Report Number(s):
- CONF-850611-; TRN: 87-010740
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BRAIN
METABOLISM
MORPHOLOGICAL CHANGES
PATHOLOGICAL CHANGES
POSITRON COMPUTED TOMOGRAPHY
GLUCOSE
CHILDREN
DYNAMIC FUNCTION STUDIES
EMBOLI
FLUORODEOXYGLUCOSE
HEREDITARY DISEASES
INFANTS
NEONATES
PATHOLOGY
PEDIATRICS
SCINTISCANNING
AGE GROUPS
ALDEHYDES
ANTIMETABOLITES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
HEXOSES
MEDICINE
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
SACCHARIDES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques
550801 - Morphology- Tracer Techniques
550501 - Metabolism- Tracer Techniques