Tumor growth delay studies in patients with multiple metastatic nodules: practical difficulties

Journal Article · Tue Jul 01 00:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90327-2· OSTI ID:6757877

Urtasun, R C ^[1]; Band, P; Ferri, H

---

1. Univ. of Alberta, Edmonton

The tumor growth delay assay is a well accepted technique in experimental animal tumor models for the measurement of response to treatment when comparing new treatment modalities. Patients have several measurabe metastatic nodules provide a good opportunity to measure the effects of new treatments as the patient can be used as his own matched control. Regression and regrowth of the treated lesions can be measured and differences can be assessed in terms of growth delay. The present material consists of a group of patients treated with fixed, single doses of radiation and single doses of the radiosensitizer, Metronidazole. The same amount of radiation was delivered to the test and control lesions; the test lesion was treated in combination with the drug. An unexpected high number of invalidations and occasional lack of reproducibility have been encountered with the first six patients. Investigation using this mehod for the first time should be aware of some of its pitfalls.

• OSTI ID: 6757877
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:7
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
METASTASES
BIOLOGICAL RADIATION EFFECTS
METRONIDAZOLE
RADIOSENSITIVITY EFFECTS
CESIUM 137
EXTERNAL IRRADIATION
GROWTH
INHIBITION
LOCAL IRRADIATION
PATIENTS
RADIATION DOSES
ALCOHOLS
ALKALI METAL ISOTOPES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CESIUM ISOTOPES
DOSES
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
IRRADIATION
ISOTOPES
NITRO COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
YEARS LIVING RADIOISOTOPES
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)