Role of NMR in diagnosis and evaluation of stroke: 303 studies of 152 patients
Nuclear Magnetic Resonance (NMR) proton imaging of 158 patients with clinical stroke was done over 18 months (0.15T Technicare resistive prototype imager). Spin echo (TR250-2150, TE30-240 m sec.) and inversion spin echo (TR1600, TI450, TE30 m sec.) sequences were used. Early sensitivity of NMR was superior to CT and 24 and 48 hours but not at 48-72 hours from clinical onset. Cerebral hemorrhage was studied by NMR in 18 patients (7 within 72 hours); all could be diagnosed as hemorrhage within 72 hours though findings were more subtle than CT. NMR findings became striking by 5 days and persisted longer than CT on late follow-up. Increased NMR signal on spin echo imaging in acute stroke correlated with tissue oedema and necrosis on pathologic study, while high signal in sub-acute stroke corresponded to gliosis, microcystic change, and macrophage infiltration. Zones of altered TI-weighted signal are presently under comparison by digitizer to pathologic zones in a patient with cerebral hemorrhage. NMR convincingly demonstrates superior early sensitivity in diagnoses of stroke but uncertainty remains concerning reliable detection of early hemorrhage.
- Research Organization:
- St. Joseph's Research Institute, London, Ontario
- OSTI ID:
- 6757242
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
Similar Records
Proton NMR imaging in experimental ischemic infarction
Cerebral Venous Congestion as Indication for Thrombolytic Treatment
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
HEMATOMAS
NMR IMAGING
CEREBRAL ARTERIES
HEMORRHAGE
DIAGNOSIS
RELIABILITY
SENSITIVITY
EVALUATION
PATHOLOGICAL CHANGES
PATHOLOGY
PATIENTS
ARTERIES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
NERVOUS SYSTEM
ORGANS
SYMPTOMS
550900* - Pathology
550602 - Medicine- External Radiation in Diagnostics- (1980-)