Schilling evaluation of pernicious anemia: current status

Zuckier, L S; Chervu, L R

Title: Schilling evaluation of pernicious anemia: current status

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Abstract

The Schilling examination remains a popular means of evaluating in vivo absorption of vitamin B/sub 12/. When absorption is abnormally low, the test may be repeated with addition to exogenous intrinsic factor (IF) in order to correct the IF deficiency that characterizes pernicious anemia. A dual-isotope variation provides a means of performing both stages of the test simultaneously, thereby speeding up the test and reducing dependence on complete urine collection. In vivo studies indicate that, when administered simultaneously, the absorption of unbound B/sub 12/ is elevated, and IF-bound B/sub 12/ is reduced, in pernicious-anemia patients, relative to the classic two-stage examination. A number of clinical studies indicate significant difficulty in resolving clincial diagnoses with the dual-tracer test. An algorithm is offered for selecting the most suitable variation of the Schilling test to improve the accuracy of test results and the ease of performance.

Authors:: Zuckier, L S; Chervu, L R

Publication Date:: Sat Sep 01 00:00:00 EDT 1984

Research Org.:: Albert Einstein Coll. of Medicine, Bronx, NY

OSTI Identifier:: 6757006

Resource Type:: Journal Article

Journal Name:: J. Nucl. Med.; (United States)

Additional Journal Information:: Journal Volume: 25:9

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; ANEMIAS; DIAGNOSIS; VITAMIN B-12; RADIOASSAY; ABSORPTION; ALGORITHMS; COBALT 57; COBALT 58; PATIENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COBALT ISOTOPES; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEMATINICS; HEMATOLOGIC AGENTS; HEMIC DISEASES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATHEMATICAL LOGIC; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; SYMPTOMS; VITAMIN B GROUP; VITAMINS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

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                    Zuckier, L S, and Chervu, L R. Schilling evaluation of pernicious anemia: current status.  United States: N. p., 1984. 
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                    Zuckier, L S, & Chervu, L R. Schilling evaluation of pernicious anemia: current status.  United States.

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                    Zuckier, L S, and Chervu, L R. 1984.  
        "Schilling evaluation of pernicious anemia: current status".  United States.

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@article{osti_6757006,

  title        = {Schilling evaluation of pernicious anemia: current status},

  author       = {Zuckier, L S and Chervu, L R},

  abstractNote = {The Schilling examination remains a popular means of evaluating in vivo absorption of vitamin B/sub 12/. When absorption is abnormally low, the test may be repeated with addition to exogenous intrinsic factor (IF) in order to correct the IF deficiency that characterizes pernicious anemia. A dual-isotope variation provides a means of performing both stages of the test simultaneously, thereby speeding up the test and reducing dependence on complete urine collection. In vivo studies indicate that, when administered simultaneously, the absorption of unbound B/sub 12/ is elevated, and IF-bound B/sub 12/ is reduced, in pernicious-anemia patients, relative to the classic two-stage examination. A number of clinical studies indicate significant difficulty in resolving clincial diagnoses with the dual-tracer test. An algorithm is offered for selecting the most suitable variation of the Schilling test to improve the accuracy of test results and the ease of performance.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6757006},
  journal      = {J. Nucl. Med.; (United States)},
number       = ,

  volume       = 25:9,

  place        = {United States},

  year         = {Sat Sep 01 00:00:00 EDT 1984},

  month        = {Sat Sep 01 00:00:00 EDT 1984}

}

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