Volume loading improves low cardiac output in experimental right ventricular infarction. [Dogs]

Journal Article · Mon Aug 01 00:00:00 EDT 1983 · J. Am. Coll. Cardiol.; (United States)

DOI:https://doi.org/10.1016/S0735-1097(83)80163-6· OSTI ID:6749382

Goldstein, J A; Vlahakes, G J; Verrier, E D; Schiller, N B; Botvinick, E; Tyberg, J V; Parmley, W W; Chatterjee, K

To evaluate the effect of volume loading in the low output state associated with right ventricular infarction, isolated right ventricular infarction was produced in seven dogs with the pericardium intact. Volume loading and pericardiotomy were then sequentially performed. After the production of right ventricular infarction, right ventricular systolic pressure decreased by 25%, aortic pressure by 36% and cardiac output by 32%. Right ventricular ejection fraction decreased by 57%, but left ventricular ejection fraction did not change significantly. Left ventricular transmural pressure and diastolic size decreased, and right ventricular diastolic size increased. Intrapericardial pressure increased and equalization of diastolic pressures was noted. Volume loading resulted in increased right ventricular systolic pressure and stroke work, increased aortic pressure and cardiac output and increased transmural pressure and diastolic size in both ventricles. Pericardiotomy resulted in further increases in right and left ventricular filling, stroke work and cardiac output, as well as resolution of equalized diastolic pressures. These results indicate that cardiac output in experimental right ventricular infarction increases with volume loading, which enhances left ventricular preload by augmenting right ventricular output. Elevated intrapericardial pressure affects filling of both ventricles and may play a role in the pathophysiology of low cardiac output in right ventricular infarction.

• Research Organization: Univ. of California, San Francisco, CA (United States)
• OSTI ID: 6749382
• Journal Information: J. Am. Coll. Cardiol.; (United States), Vol. 2:2
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
DYNAMIC FUNCTION STUDIES
SCINTISCANNING
VOLUME
TECHNETIUM 99
BLOOD PRESSURE
DOGS
ISOMERIC NUCLEI
MYOCARDIAL INFARCTION
ANIMALS
BETA DECAY RADIOISOTOPES
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INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
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TECHNETIUM ISOTOPES
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YEARS LIVING RADIOISOTOPES
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