Effects of oral contraceptives, or lanosterol, on ADP-induced aggregation and binding of /sup 125/I-fibrinogen to rat platelets

Journal Article · Thu Mar 01 00:00:00 EST 1984 · Thromb. Res.; (United States)

DOI:https://doi.org/10.1016/0049-3848(84)90017-3· OSTI ID:6748773

McGregor, L; Toor, B; McGregor, J L; Renaud, S; Clemetson, K J

The aggregation to ADP and the binding of /sup 125/I-fibrinogen to platelets from rats treated with oral contraceptives or normal platelets treated in vitro with lanosterol were compared to their respective controls. Both types of platelets showed a significant increase in ADP-induced aggregation and in binding of fibrinogen, indicating that the effect of oral contraceptives could be partly due to increased levels of lanosterol in platelet membrane.

• Research Organization: Laboratoire d'Hemobiologie, Faculte de Medecine, UER Alexis Carrel, Lyon, France
• OSTI ID: 6748773
• Journal Information: Thromb. Res.; (United States), Vol. 33:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD PLATELETS
CHEMICAL BONDS
FIBRINOGEN
ADP
DRUGS
IODINE 125
LABELLED COMPOUNDS
RECEPTORS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BODY FLUIDS
COAGULANTS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
HEMATOLOGIC AGENTS
HEMOSTATICS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MATERIALS
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques