Limited epizootic of neuroblastoma in coho salmon reared in chlorinated-dechlorinated water
During the 1976-77 brood year, approximately 12 cases of neuroblastoma were observed in a captive group of 100,000 fingerling coho salmon (Oncorhynchus kisutch) reared in a commercial hatchery. The tumors were large, occurring in the skeletal muscle near the dorsal fin causing conspicuous bulging of the overlying integument. Tumors examined from 3 fish each consisted of neuroblasts in trabecular patterns interspersed by glial fibrillar material and linear cavities resembling central neural canals lined by ependyma-like cells. Ganglion-like cells also were apparent morphologically and by special stain. Cancer of the tumor was characterized by an abundance of mitotic figures with occasional abnormal divisions, local invasion of normal tissues, and potentially metastatic tumor cell aggregates in organ vasculature. The etiology of this tumor may have been related to mutagenic-carcinogenic halogenated compounds possibly formed in the hatchery water supply during continuous chlorination of incoming river water.
- Research Organization:
- Oregon State Univ., Corvallis
- OSTI ID:
- 6748154
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Vol. 72:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED ALIPHATIC HYDROCARBONS
BIOLOGICAL EFFECTS
CHLORINATED AROMATIC HYDROCARBONS
SALMON
NEOPLASMS
CHLORINATION
RIVERS
ANADROMOUS FISHES
ANIMALS
AQUATIC ORGANISMS
AROMATICS
CHEMICAL REACTIONS
DISEASES
FISHES
HALOGENATED ALIPHATIC HYDROCARBONS
HALOGENATED AROMATIC HYDROCARBONS
HALOGENATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
STREAMS
SURFACE WATERS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)