Antagonists for acute oral cadmium chloride intoxication

Journal Article · Fri Jan 01 00:00:00 EST 1988 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398809531095· OSTI ID:6744486

Basinger, M A; Jones, M M; Holscher, M A; Vaughn, W K

An examination has been carried out on the relative efficacy of a number of chelating agents when acting as antagonists for oral cadmium chloride intoxication in mice. The compounds were administered orally after the oral administration of cadmium chloride at 1 mmol/kg. Of the compounds examined, several were useful in terms of enhancing survival, but by far the most effective in both enhancing survival and leaving minimal residual levels of cadmium in the liver and the kidney, was meso-2,3-dimercaptosuccinic acid (DMSA). Several polyaminocarboxylic acids also enhanced survival. The most effective of these in reducing liver and kidney levels of cadmium were diethylenetriaminepentaacetic acid (DTPA), trans-1,2-diaminocyclohexane-N,N,N'N'-tetraacetic acid (CDTA), and triethylenetetraminehexaacetic acid (TTHA). D-Penicillamine (DPA) was found to promote survival but also led to kidney cadmium levels higher than those found in the controls. Sodium 2,3-dimercaptopropane-1-sulfonate (DMPS) was as effective in promoting survival as DMSA but left levels of cadmium in the kidney and liver that were approximately four times greater than those found with DMSA.

• Research Organization: Vanderbilt Univ., Nashville, TN (USA)
• OSTI ID: 6744486
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 23:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
TOXICITY
CHELATING AGENTS
BIOLOGICAL EFFECTS
CADMIUM CHLORIDES
CDTA
DTPA
KIDNEYS
LIVER
MICE
PENICILLAMINE
SURVIVAL TIME
AMINO ACIDS
ANIMALS
BODY
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARBOXYLIC ACIDS
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
GLANDS
HALIDES
HALOGEN COMPOUNDS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOPROTECTIVE SUBSTANCES
RODENTS
THIOLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology