Effects of chronic cocaine abuse on postsynaptic dopamine receptors

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · American Journal of Psychiatry; (USA)

OSTI ID:6743771

Volkow, N D; Fowler, J S; Wolf, A P; Schlyer, D; Shiue, C Y; Alpert, R; Dewey, S L; Logan, J; Bendriem, B; Christman, D ^[1]

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1. Brookhaven National Laboratory, Upton, NY (USA)

To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated ({sup 18}F)N-methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects. Cocaine abusers who had been detoxified for 1 week or less showed significantly lower values for uptake of ({sup 18}F)N-methylspiroperidol in striatum than the normal subjects, whereas the cocaine abusers who had been detoxified for 1 month showed values comparable to those obtained from normal subjects. The authors conclude that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.

• OSTI ID: 6743771
• Journal Information: American Journal of Psychiatry; (USA), Vol. 147:6; ISSN 0002-953X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
COCAINE
BIOLOGICAL EFFECTS
DOPAMINE
RECEPTORS
NERVOUS SYSTEM DISEASES
DIAGNOSIS
BIOCHEMICAL REACTION KINETICS
CHRONIC EXPOSURE
FLUORINE 18
MAN
POSITRON COMPUTED TOMOGRAPHY
SPIPERONE
ALKALOIDS
AMINES
ANESTHETICS
ANIMALS
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LIGHT NUCLEI
MAMMALS
MEMBRANE PROTEINS
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PRIMATES
PROTEINS
PSYCHOTROPIC DRUGS
RADIOISOTOPES
REACTION KINETICS
SYMPATHOMIMETICS
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics