Inhibition of hematopoietic recovery from radiation-induced myelosuppression by natural killer cells
- Wayne State Univ. School of Medicine, Detroit, MI (USA)
We have examined the role of natural killer (NK) cells in situ in the recovery of marrow hematopoiesis in B6D2F1 mice receiving various doses of total-body irradiation (TBI) as a well-characterized model for treatment-induced myelosuppression. Applying an in situ cytotoxic approach for ablating NK 1.1 cells, we have demonstrated that NK 1.1 cells differentially inhibit the recovery of hematopoietic stem cells (CFU-S) and their progenitor cells committed to granulocyte-macrophage differentiation from a sublethal dose of TBI (9 Gy) while not affecting the recovery of progenitor cells committed to either erythroid or megakaryocyte differentiation from TBI. However, recoveries of CFU-S and progenitor cells were unaffected by the ablation of NK cells prior to a moderate dose of TBI (2 Gy). These findings provide in situ evidence that NK cells are potential inhibitors of hematopoietic recovery from treatment-induced myelosuppression.
- OSTI ID:
- 6743172
- Journal Information:
- Radiation Research; (USA), Vol. 122:2; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
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IMMUNE SYSTEM DISEASES
RADIOINDUCTION
LYMPHOCYTES
BIOLOGICAL FUNCTIONS
STEM CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL RADIATION EFFECTS
CELL DIFFERENTIATION
MACROPHAGES
MICE
WHOLE-BODY IRRADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
EXTERNAL IRRADIATION
FUNCTIONS
IRRADIATION
LEUKOCYTES
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PHAGOCYTES
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RECOVERY
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals