Myocardial perfusion abnormalities in asymptomatic patients with systemic lupus erythematosus

Journal Article · Wed Aug 01 00:00:00 EDT 1984 · Am. J. Med.; (United States)

DOI:https://doi.org/10.1016/0002-9343(84)90704-6· OSTI ID:6741157

Hosenpud, J D; Montanaro, A; Hart, M V; Haines, J E; Specht, H D; Bennett, R M; Kloster, F E

Accelerated coronary artery disease and myocardial infarction in young patients with systemic lupus erythematosus is well documented; however, the prevalence of coronary involvement is unknown. Accordingly, 26 patients with systemic lupus were selected irrespective of previous cardiac history to undergo exercise thallium-201 cardiac scintigraphy. Segmental perfusion abnormalities were present in 10 of the 26 studies (38.5 percent). Five patients had reversible defects suggesting ischemia, four patients had persistent defects consistent with scar, and one patient had both reversible and persistent defects in two areas. There was no correlation between positive thallium results and duration of disease, amount of corticosteroid treatment, major organ system involvement or age. Only a history of pericarditis appeared to be associated with positive thallium-201 results (p less than 0.05). It is concluded that segmental myocardial perfusion abnormalities are common in patients with systemic lupus erythematosus. Whether this reflects large-vessel coronary disease or small-vessel abnormalities remains to be determined.

• Research Organization: Department of Medicine, Oregon Health Sciences University, Portland
• OSTI ID: 6741157
• Journal Information: Am. J. Med.; (United States), Vol. 77:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
HEART
SCINTISCANNING
LUPUS
PATHOGENESIS
CARDIOVASCULAR DISEASES
DIAGNOSIS
ISCHEMIA
THALLIUM 201
BACTERIAL DISEASES
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
INFECTIOUS DISEASES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SKIN DISEASES
THALLIUM ISOTOPES
TUBERCULOSIS
VASCULAR DISEASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques