Competition between splicing and polyadenylation reactions determines which adenovirus region E3 mRNAs are synthesized
Journal Article
·
· Mol. Cell. Biol.; (United States)
Complex transcription units encode multiple mRNAs which arise by alternative processing of a common pre-mRNA precursor. It is not known how the pre-mRNA processing pathways are determined or controlled. The authors are investigating this problem by using the E3 complex transcription unit of adenovirus as a model. Their approach is to construct virus mutants with lesions in E3 and then determine how the mutation affects the accumulation of E3 mRNAs in vivo. They report results which indicate that competition between splicing reactions and polyadenylation reactions occurs in vivo and that this plays an important role in alternative pre-mRNA processing.
- Research Organization:
- Institute for Molecular Virology, St. Louis Univ. School of Medicine, St. Louis, MO (US)
- OSTI ID:
- 6737002
- Journal Information:
- Mol. Cell. Biol.; (United States), Vol. 8:8
- Country of Publication:
- United States
- Language:
- English
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