Changing topographic patterns of human cerebral blood flow with age measured by xenon CT
Changes in cerebral blood flow with age have been of long-standing interest. A study of 20 normal, healthy, right-handed volunteers 20-100 years old using a noninvasive method is reported. Local cerebral blood flow (LCBF) and partition coefficients (Llambda) were measured during inhalation of 35% stable xenon gas and serial computed tomographic (CT) scanning (CT-CBF). Relatively higher LCBF values were measured bilaterally in the cortex of occipital and frontal lobes; no significant differences were noted between left and right hemispheres. Significant age-related declines in LCBF values were observed for all cortical and subcortical gray and white matter regions of interest examined. Age-related declines were steepest in the cortex of the frontal lobes, particularly prefrontal cortex, caudate, putamen, and lentiform nuclei. Speech and visual cortical regions, functionally active throughout the normal life span, showed less age-related decline compared with all other regions, particularly prefrontal.
- Research Organization:
- Baylor Coll. of Medicine, Houston, TX
- OSTI ID:
- 6728011
- Journal Information:
- AJR, Am. J. Roentgenol.; (United States), Vol. 142:5
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BLOOD FLOW
AGE DEPENDENCE
PHYSIOLOGY
CEREBRUM
COMPUTERIZED TOMOGRAPHY
XENON 133
INHALATION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
EVEN-ODD NUCLEI
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
TOMOGRAPHY
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550602 - Medicine- External Radiation in Diagnostics- (1980-)
551000 - Physiological Systems