Effect of fluorocarbon-for-blood exchange on regional blood flow in rats

Journal Article · Fri Apr 01 00:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:6724821

Lee, P A; Sylvia, A L; Piantadosi, C A ^[1]

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1. Duke Univ. Medical Center, Durham, NC (USA)

Cerebrocirculatory responses to total perfluorocarbon (FC-43)-for-blood replacement were studied in anesthetized, ventilated rats breathing 100% O{sub 2}. Changes in total and regional cerebral blood flow (CBF) were measured using the radiolabeled-microsphere technique. The data were compared with two control groups of hemoglobin-circulated animals; one group was exposed to arterial hypoxia and the other to isovolemic hemodilution with Krebs-Henseleit-albumin (KHA) solution. Exchange transfusion with FC-43 doubled total and regional CBF, causing preferential flow increases to the cortex and cerebellum. Estimated cerebrovascular resistance fell to 50% of the preexchange value. Both hemodilution and hypoxia control experiments produced CBF responses similar to those obtained in FC-43 animals. Although calculated arterial O{sub 2} contents in all three groups of animals were similar, blood viscosity was normal in hypoxic rats and reduced in KHA and FC-43 animals. Since arterial and cerebrovenous Po{sub 2}s were both high in fluorocarbon-circulated rats, over results suggest that decreased O{sub 2} content and perhaps lower viscosity of the circulating fluorocarbon were responsible for increases in CBF required to maintain sufficient delivery of O{sub 2} to the brain.

• OSTI ID: 6724821
• Journal Information: American Journal of Physiology; (USA), Vol. 254:4; ISSN 0002-9513
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD FLOW
RADIOASSAY
BLOOD SUBSTITUTES
TRANSFUSIONS
CEREBRUM
METABOLISM
BLOOD PRESSURE
CERIUM 141
MICROSPHERES
NIOBIUM 95
OXYGEN
RATS
RUTHENIUM 103
TIN 113
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CERIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HEMATOLOGIC AGENTS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NIOBIUM ISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RODENTS
RUTHENIUM ISOTOPES
THERAPY
TIN ISOTOPES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques