A pilot study with ethyl bis (2,2-dimethyl-1-aziridinyl) phosphinate (AB-163) and radiation therapy
Ethyl bis (2,2-dimethyl-1-aziridinyl) phosphinate (AB-163), a TEPA analogue, was used with radiation therapy in treating 18 patients with advanced malignancies. There were 12 patients with esophageal carcinoma; 3 with adenocarcinomas of the gastrointestinal tract; one, squamous carcinoma of the cervix; and one, adenocarcinoma of the ovary. One hundred mg/M/sup 2/ AB-163 was given by rapid i.v. drip one half-hour before conventional radiation therapy. The majority of patients received 10 combined treatments. Three of those with squamous cell carcinomas (two in the esophagus and one in the cervix) remained disease-free for more than 2 years. One with liver metastasis and unresectable carcinoma of the stomach survived for 9 months. The drug causes side effects mainly involving the central nervous system and gastrointestinal tract. Drug-related myelosuppression has not been observed. The mode of action is speculated to be a result of active intermediate hydrolysis products which appear capable of phosphorylating X ray induced DNA strand damage. However, much additional investigation is required, both in vitro and clinically, before its efficacy and safety can be demonstrated.
- Research Organization:
- Virginia Commonwealth Univ., Richmond
- OSTI ID:
- 6724583
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8:7
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
RADIOSENSITIVITY EFFECTS
SIDE EFFECTS
STRAND BREAKS
RADIOINDUCTION
AZINES
CARCINOMAS
CESIUM 137
DNA
ESOPHAGUS
GAMMA RADIATION
GASTROINTESTINAL TRACT
MEV RANGE 01-10
OVARIES
PATIENTS
PHOSPHINES
PHOTON BEAMS
RADIATION SOURCE IMPLANTS
RADIOTHERAPY
UTERUS
ALKALI METAL ISOTOPES
BEAMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CESIUM ISOTOPES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ENERGY RANGE
FEMALE GENITALS
GONADS
HETEROCYCLIC COMPOUNDS
IMPLANTS
IONIZING RADIATIONS
ISOTOPES
MEDICINE
MEV RANGE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHOSPHORUS COMPOUNDS
RADIATION SOURCES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
THERAPY
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine
560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
560151 - Radiation Effects on Animals- Man
560161 - Radionuclide Effects
Kinetics
& Toxicology- Man