Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients
The results of this study demonstrate that spleen cells taken from mice at the height of the primary immune response to intravenous infection with Mycobacterium tuberculosis possess the capacity to transfer adoptive protection to M. tuberculosis-infected recipients, but only if these recipients are first rendered T cell-deficient, either by thymectomy and gamma irradiation, or by sublethal irradiation. A similar requirement was necessary to demonstrate the adoptive protection of the lungs after exposure to an acute aerosol-delivered M. tuberculosis infection. In both infectious models successful adoptive immunotherapy was shown to be mediated by T lymphocytes, which were acquired in the donor animals in response to the immunizing infection. It is proposed that the results of this study may serve as a basic model for the subsequent analysis of the nature of the T cell-mediated immune response to both systemic and aerogenic infections with M. tuberculosis.
- Research Organization:
- Trudeau Inst. Inc., Saranac Lake, NY
- OSTI ID:
- 6723030
- Journal Information:
- J. Exp. Med.; (United States), Vol. 158:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
MICE
BIOLOGICAL RADIATION EFFECTS
IMMUNE REACTIONS
MYCOBACTERIUM TUBERCULOSIS
IMMUNOTHERAPY
GAMMA RADIATION
LUNGS
LYMPHOCYTES
SPLEEN CELLS
THYMECTOMY
ANIMAL CELLS
ANIMALS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
LEUKOCYTES
MAMMALS
MATERIALS
MEDICINE
MICROORGANISMS
MYCOBACTERIUM
ORGANS
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
SURGERY
THERAPY
VERTEBRATES
560151* - Radiation Effects on Animals- Man
550700 - Microbiology
551000 - Physiological Systems