Carcinogenicity of deuterium-labeled N-nitroso-N-methylcyclohexylamine in rats
Journal Article
·
· JNCI, J. Natl. Cancer Inst.; (United States)
OSTI ID:6719356
F344 rats were treated with both unlabeled N-nitroso-N-methylcyclohexylamine (NMC) and deuterium-labeled NMC (NMC-d3) in the methyl group. Both compounds were administered in the drinking water at concentrations of 50 and 12.5 mg/liter. The NMC-d3 was not less carcinogenic than the unlabeled NMC, which suggested that oxidation of the methyl group is not a rate-limiting step in the induction of esophageal tumors.
- Research Organization:
- NCI Frederick Cancer Research Center, MD
- OSTI ID:
- 6719356
- Journal Information:
- JNCI, J. Natl. Cancer Inst.; (United States), Vol. 64:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
COMPARATIVE EVALUATIONS
DEUTERIUM COMPOUNDS
RADIONUCLIDE KINETICS
ESOPHAGUS
BIOLOGICAL EFFECTS
CARCINOGENESIS
NITROSO COMPOUNDS
NEOPLASMS
RATS
ANIMALS
BODY
DIGESTIVE SYSTEM
DISEASES
HYDROGEN COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
AMINES
COMPARATIVE EVALUATIONS
DEUTERIUM COMPOUNDS
RADIONUCLIDE KINETICS
ESOPHAGUS
BIOLOGICAL EFFECTS
CARCINOGENESIS
NITROSO COMPOUNDS
NEOPLASMS
RATS
ANIMALS
BODY
DIGESTIVE SYSTEM
DISEASES
HYDROGEN COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)