Mouse models of human thalassemia
Conference
·
OSTI ID:6718874
The group of diseases called the thalassemias is the largest single-gene health problem in the world according the World Health Organization. The thalassemias are lethal hereditary anemias in which the infants cannot make their own blood. Three mouse mutants are shown to be models of the human disease ..cap alpha..-thalassemia. However, since an additional gene is affected, these mutants represent a particularly severe condition in which death occurs in the homozygous embryo even before globin genes are activated. Phenotypic and genotypic characteristics are described. (ACR)
- Research Organization:
- National Heart, Lung, and Blood Inst., Bethesda, MD (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6718874
- Report Number(s):
- CONF-8110243-1; ON: DE83001946
- Resource Relation:
- Conference: International symposium on animal models of inherited metabolic disease, Bethesda, MD, USA, 19 Oct 1981; Other Information: Portions of document are illegible
- Country of Publication:
- United States
- Language:
- English
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