Measurement of regional cerebral blood flow in cat brain using intracarotid 2H2O and 2H NMR imaging

Journal Article · Tue May 01 00:00:00 EDT 1990 · Magnetic Resonance in Medicine; (USA)

DOI:https://doi.org/10.1002/mrm.1910140223· OSTI ID:6717511

Detre, J A; Subramanian, V H; Mitchell, M D; Smith, D S; Kobayashi, A; Zaman, A; Leigh, Jr, J S ^[1]

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1. Univ. of Pennsylvania School of Medicine, Philadelphia (USA)

Cerebral blood flow (CBF) was measured in cat brain in vivo at 2.7 T using 2H NMR to monitor the washout of deuterated saline injected into both carotid arteries via the lingual arteries. In anesthetized cats, global CBF varied directly with PaCO{sub 2} over a range of 20-50 mm Hg, and the corresponding global CBF values ranged from 25 to 125 ml.100 g-1.min-1. Regional CBF was measured in a 1-cm axial section of cat brain using intracarotid deuterated saline and gradient-echo 2H NMR imaging. Blood flow images with a maximum pixel resolution of 0.3 x 0.3 x 1.0 cm were generated from the deuterium signal washout at each pixel. Image derived values for CBF agreed well with other determinations, and decreased significantly with hypocapnia.

• OSTI ID: 6717511
• Journal Information: Magnetic Resonance in Medicine; (USA), Vol. 14:2; ISSN 0740-3194
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NMR IMAGING
CEREBRAL CORTEX
BLOOD FLOW
VASCULAR DISEASES
DIAGNOSIS
CAROTID ARTERIES
CATS
DEUTERIUM
NUCLEAR MAGNETIC RESONANCE
ANIMALS
ARTERIES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRUM
DIAGNOSTIC TECHNIQUES
DISEASES
HYDROGEN ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANS
RESONANCE
STABLE ISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics