Delayed onset of gastrointestinal disease in the recipients of bone marrow transplants: a variant graft-versus-host reaction

Journal Article · Thu Jul 01 00:00:00 EDT 1982 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198207000-00011· OSTI ID:6716976

Serota, F T; Rosenberg, H K; Rosen, J; Koch, P A; August, C S

The report describes a subacute syndrome consisting of anorexia, mouth ulcers, abdominal pain, and diarrhea which occurred in three allogenic transplant recipients which appears to be distinct from the usual patterns of acute or chronic graft-versus-host disease (GVHD). The patient with myelomonocytic leukemia was treated with cyclophosphamide (60 mg/kg) i.v. 4 and 3 days before and total body X irradiation to 800 rad 1 day before transplantation. The radiation was administered from a 6-Mev source at least 3.5 m from the patient via opposing lateral fields. The patients were maintained in the protected environment until their absolute neutrophil counts (ANC) became greater than 1000/mm/sup 3/. All blood products were irradiated (1500 rad) prior to transfusion. Methotrexate was administered weekly for 100 days to prevent GVHD. (JMT)

• Research Organization: Univ. of Pennsylvania-Childrens Hospital of PA
• OSTI ID: 6716976
• Journal Information: Transplantation; (United States), Vol. 34:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IMMUNE REACTIONS
BIOLOGICAL RADIATION EFFECTS
TRANSPLANTS
GRAFT-HOST REACTION
BONE MARROW
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
MEDICAL SUPPLIES
PATIENTS
WHOLE-BODY IRRADIATION
X RADIATION
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
IRRADIATION
ORGANS
RADIATION EFFECTS
RADIATIONS
TISSUES
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man