Diffuse interstitial pulmonary fibrosis: pulmonary fibrosis in mice induced by treatment with butylated hydroxytoluene and oxygen

Journal Article · Tue Dec 01 00:00:00 EST 1981 · Am. J. Pathol.; (United States)

OSTI ID:6716008

Haschek, W M ^[1]; Brody, A R; Klein-Szanto, A J.P.; Witschi, H

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1. Oak Ridge National Lab., TN

It is proposed that the pulmonary fibrosis induced in mice by treatment with BHT and oxygen is a good experimental model for human pulmonary fibrosis. The mechanism of synergistic and additive effects of various agents on pulmonary injury and the epithelial mesenchymal interactions occurring during the early and late phases of lung repair could be studied. This model could be used for study of the effects of various concentrations of oxygen on diffusely damaged lung and assessment of the efficacy of drugs in preventing or resolving excessive collagen accumulation in lung. In addition, the relationship between pulmonary fibrosis and emphysema could be studied.

• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6716008
• Journal Information: Am. J. Pathol.; (United States), Vol. 105:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CRESOLS
BIOLOGICAL EFFECTS
SYNERGISM
FIBROSIS
BIOLOGICAL MODELS
OXYGEN
CELL PROLIFERATION
HYDROXYPROLINE
LUNGS
MICE
PNEUMONITIS
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
AZOLES
BODY
CARBOXYLIC ACIDS
ELEMENTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
HYDROXY COMPOUNDS
MAMMALS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PHENOLS
PYRROLES
PYRROLIDINES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
550901* - Pathology- Tracer Techniques