Marrow toxicity of fractionated vs. single dose total body irradiation is identical in a canine model
- Univ. of Washington School of Public Health and Community Medicine, Seattle, WA (United States)
The authors explored in dogs the marrow toxicity of single dose total body irradiation delivered from two opposing [sup 60]Co sources at a rate of 10 cGy/min and compared results to those seen with total body irradiation administered in 100 cGy fractions with minimum interfraction intervals of 6 hr. Dogs were not given marrow transplants. They found that 200 cGy single dose total body irradiation was sublethal, with 12 of 13 dogs showing hematopoietic recovery and survival. Seven of 21 dogs given 300 cGy single dose total body irradiation survived compared to 6 of 10 dogs given 300 cGy fractionated total body irradiation. One of 28 dogs given 400 cGy single dose total body irradiation survived compared to none of six given fractionated radiation. With granulocyte colony stimulating factor (GCSF) administered from day 0-21 after 400 cGy total body irradiation, most dogs survived with hematological recovery. Because of the almost uniform success with GCSF after 400 cGy single dose total body irradiation, a study of GCSF after 400 cGy fractionated total body irradiation was deemed not to be informative and, thus, not carried out. Additional comparisons between single dose and fractionated total body irradiation were carried out with GCSF administered after 500 and 600 cGy of total body irradiation. As with lower doses of total body irradiation, no significant survival differences were seen between the two modes of total body irradiation, and only 3 of 26 dogs studied survived with complete hematological recovery. Overall, therefore, survival among dogs given single dose total body irradiation was not different from that of dogs given fractionated total body irradiation (p = .67). Similarly, the slopes of the postirradiation declines of granulocyte and platelet counts and the rates of their recovery in surviving dogs given equal total doses of single versus fractionated total body irradiation were indistinguishable. 24 refs., 3 figs., 2 tabs.
- OSTI ID:
- 6714112
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics; (United States), Vol. 26:2; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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BONE MARROW
BIOLOGICAL RADIATION EFFECTS
DOGS
WHOLE-BODY IRRADIATION
FRACTIONATED IRRADIATION
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IRRADIATION
MAMMALS
ORGANS
RADIATION EFFECTS
TISSUES
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560152* - Radiation Effects on Animals- Animals