Patterns of brain activity in normals and schizophrenics with positron emission tomography
The authors investigated the functional interaction among brain areas under baseline and upon activation by a visual task to compare the response of normal subjects from the ones of chronic schizophrenics. Cerebral metabolic images were obtained on twelve healthy volunteers an eighteen schizophrenics with positron emission tomography and 11-C-Deoxyglucose. Correlation coefficients among the relative metabolic values (region of interest divided by the average of whole brain gray matter) of 11 brain regions; frontal, parietal, temporal and occipital left and right lobes, left and right basal ganglia and thalamus were computed for the baseline and for the task. Under baseline, normals showed more functional correlations than schizophrenics. Both groups showed a thalamo-occipital (positive) and thalamo-frontal (negative) interaction. The highest correlations among homologous brain areas were the frontal, occipital and basal ganglia.
- Research Organization:
- Brookhaven National Labs., Upton, NY
- OSTI ID:
- 6710728
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CEREBRAL CORTEX
PHYSIOLOGY
CEREBRUM
PATHOLOGICAL CHANGES
POSITRON COMPUTED TOMOGRAPHY
GLUCOSE
DIAGNOSTIC USES
LABELLING
MENTAL DISORDERS
DIAGNOSIS
THALAMUS
VISION
CARBON 11
CORRELATIONS
DIAGNOSTIC TECHNIQUES
IMAGES
METABOLIC ACTIVATION
PATIENTS
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HEXOSES
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550602 - Medicine- External Radiation in Diagnostics- (1980-)
551000 - Physiological Systems
550100 - Behavioral Biology