Maturation of normal primate white matter: computed tomographic correlation

Journal Article · Wed Sep 01 00:00:00 EDT 1982 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.139.3.561· OSTI ID:6710217

Quencer, R M

Five infant baboons were examined with computed tomography (CT) during the first year of their lives to determine the rate and degree of normal white matter maturation in frontal, occipital, and parietal areas. The increase in CT numbers with age was correlated with gross and histologic specimens. Two phases of maturation were identified: a rapid phase (first 8-12 weeks) and a gradual phase (after 12 weeks). Frontal white matter was the most immature in the immediate postnatal period but it became equal in attenuation to the other regions by 4 weeks of age. Knowledge of white matter maturation rates may be particularly useful in cases of neonatal hypoxia/ischemia where zones of periventricular hypodensity are identified. The failure of such regions to follow a normal rate of maturation may indicate damage to the white matter and have significant prognostic implications.

• Research Organization: Univ of Miami School of Medicine, FL
• OSTI ID: 6710217
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Vol. 139:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
COMPUTERIZED TOMOGRAPHY
PATHOLOGICAL CHANGES
AGE DEPENDENCE
APES
DIAGNOSIS
GROWTH
INFANTS
AGE GROUPS
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
CHILDREN
DIAGNOSTIC TECHNIQUES
MAMMALS
NERVOUS SYSTEM
ORGANS
PRIMATES
TOMOGRAPHY
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)