Myelin imaging with C-11 labeled diphenylmethanol and positron emission tomography
The authors have recently studied several C-11-labeled radiopharmaceuticals for their suitability as myelin imaging agents with positron emission tomography (PET). C-11 diphenylmethanol (DPM) was selected on the basis of its in vivo metabolic stability and high extraction and lipophilicity. PET studies were performed in three normal subjects and in one patient with multiple sclerosis (MS). Myelin distribution was imaged following the bolus intravenous administration of 25-30 mCi of C-11 DPM. Sequential scans were obtained after radiotracer administration to measure the DPM distribution as a function of time. In addition, regional cerebral blood flow was measured after the bolus intravenous injection of 0-15 water. A tomographic slice through the centrum semiovale was used to obtain regional data for gray matter (GM) and white matter (WM).
- Research Organization:
- Washington Univ. School of Medicine, St. Louis, MO
- OSTI ID:
- 6709214
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BENZHYDROL
DIAGNOSTIC USES
LABELLING
CEREBRUM
NERVOUS SYSTEM DISEASES
POSITRON COMPUTED TOMOGRAPHY
MYELIN
DIAGNOSIS
WATER
BIOLOGICAL ACCUMULATION
BLOOD FLOW
CARBON 11
IN VIVO
INTRAVENOUS INJECTION
METABOLIC ACTIVATION
METABOLISM
OXYGEN 15
PATIENTS
RADIONUCLIDE ADMINISTRATION
RADIOPHARMACEUTICALS
TIME DEPENDENCE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
ALCOHOLS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON ISOTOPES
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEMBRANES
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
RADIOISOTOPES
TOMOGRAPHY
USES
550602* - Medicine- External Radiation in Diagnostics- (1980-)