Boronated antibodies and promazine derivatives for potential neutron capture therapy
The theoretical basis for boron neutron capture therapy (BNCT) derives from the irradiation of /sup 10/B with thermal neutrons, resulting in a fission reaction yielding /sup 7/Li and alpha particles. The fission products have short path lengths and high linear energy transfer (LET). Each component of this binary system, thermal neutrons and /sup 10/B, independently are nontumoricidal, but together they can be highly lethal. Success depends on localizing enough of the /sup 10/B (approx.20 ..mu..g/g of tumor) and delivering a requisite fluence of thermal neutrons (approx.10/sup 13/ n/cm/sup 9/) at the site of the tumor. This report describes the boronation of antibodies and the development of boron-containing promazine derivatives to selectively deliver /sup 10/B to tumor cells for BNCT.
- Research Organization:
- Ohio State Univ., Columbus
- OSTI ID:
- 6708250
- Report Number(s):
- CONF-861102-
- Journal Information:
- Trans. Am. Nucl. Soc.; (United States), Vol. 53; Conference: American Nuclear Society and Atomic Industrial Forum joint meeting, Washington, DC, USA, 16 Nov 1986
- Country of Publication:
- United States
- Language:
- English
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BORON 10
UPTAKE
BORON COMPOUNDS
SYNTHESIS
NEUTRON CAPTURE THERAPY
FISSION PRODUCTS
IRRADIATION
MONOCLONAL ANTIBODIES
ANTIBODIES
BORON ISOTOPES
ISOTOPES
LIGHT NUCLEI
MATERIALS
MEDICINE
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
RADIOACTIVE MATERIALS
RADIOLOGY
RADIOTHERAPY
STABLE ISOTOPES
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)